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polyclonal rabbit anti human cd107a (Bio-Rad)

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Bio-Rad polyclonal rabbit anti human cd107a

Peripheral circulating <t>CD107a</t> + CD8 + T-cells. (A) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), SLE-patients (SLE), (B) patients with lupus nephritis (with LN) and without lupus nephritis (without LN) are shown. (C) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), active SLE-patients (SLE) and inactive patients are shown. Frequencies of these T-cells are shown. Horizontal lines represent the mean. P -values were calculated using the non-parametric Mann-Whitney U-test. (D) Correlation between percentages of CD107a + CD8 + T-cells and disease activity ( n = 30) as assessed by the systemic lupus erythematosus disease activity index (SLEDAI). Spearman analysis was performed to calculate the correlation. A p -value <0.05 was considered significant. (E) A representative dot plot of the flow-cytometry staining is shown for a healthy control (HC), a patient with lupus nephritis (LN) and without LN. The corresponding isotype control is illustrated.

Polyclonal Rabbit Anti Human Cd107a, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 93/100, based on 21 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 21 article reviews

polyclonal rabbit anti human cd107a - by Bioz Stars, 2026-05

93/100 stars

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1) Product Images from "CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients"

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

Journal: Frontiers in Medicine

doi: 10.3389/fmed.2021.556776

Peripheral circulating CD107a + CD8 + T-cells. (A) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), SLE-patients (SLE), (B) patients with lupus nephritis (with LN) and without lupus nephritis (without LN) are shown. (C) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), active SLE-patients (SLE) and inactive patients are shown. Frequencies of these T-cells are shown. Horizontal lines represent the mean. P -values were calculated using the non-parametric Mann-Whitney U-test. (D) Correlation between percentages of CD107a + CD8 + T-cells and disease activity ( n = 30) as assessed by the systemic lupus erythematosus disease activity index (SLEDAI). Spearman analysis was performed to calculate the correlation. A p -value <0.05 was considered significant. (E) A representative dot plot of the flow-cytometry staining is shown for a healthy control (HC), a patient with lupus nephritis (LN) and without LN. The corresponding isotype control is illustrated.

Figure Legend Snippet: Peripheral circulating CD107a + CD8 + T-cells. (A) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), SLE-patients (SLE), (B) patients with lupus nephritis (with LN) and without lupus nephritis (without LN) are shown. (C) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), active SLE-patients (SLE) and inactive patients are shown. Frequencies of these T-cells are shown. Horizontal lines represent the mean. P -values were calculated using the non-parametric Mann-Whitney U-test. (D) Correlation between percentages of CD107a + CD8 + T-cells and disease activity ( n = 30) as assessed by the systemic lupus erythematosus disease activity index (SLEDAI). Spearman analysis was performed to calculate the correlation. A p -value <0.05 was considered significant. (E) A representative dot plot of the flow-cytometry staining is shown for a healthy control (HC), a patient with lupus nephritis (LN) and without LN. The corresponding isotype control is illustrated.

Techniques Used: MANN-WHITNEY, Activity Assay, Flow Cytometry, Staining, Control

(A) The proportion of CD107a + CD8 + T-cells we were analyzed according to the immunosuppressive treatment. Patients were subgrouped in (i) no treatment or prednisone alone (ii) prednisone and mycophenolate mofetil, azathioprine or cyclosporine (iii) prednisone and hydroxychloroquine (iv) prednisone and hydroxychloroquine combined with mycophenolate mofetil, azathioprine or cyclosporine. Patients were compared to healthy controls (HC). P -values were calculated using the non-parametric Mann-Whitney U-test. (B) Correlation between percentages of CD107a + CD8 + T-cells for all samples taken ( n = 30) daily dose of hydroxychloroquine is shown. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Figure Legend Snippet: (A) The proportion of CD107a + CD8 + T-cells we were analyzed according to the immunosuppressive treatment. Patients were subgrouped in (i) no treatment or prednisone alone (ii) prednisone and mycophenolate mofetil, azathioprine or cyclosporine (iii) prednisone and hydroxychloroquine (iv) prednisone and hydroxychloroquine combined with mycophenolate mofetil, azathioprine or cyclosporine. Patients were compared to healthy controls (HC). P -values were calculated using the non-parametric Mann-Whitney U-test. (B) Correlation between percentages of CD107a + CD8 + T-cells for all samples taken ( n = 30) daily dose of hydroxychloroquine is shown. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Techniques Used: MANN-WHITNEY

CD8 + and CD107a + T-cell infiltrates in lupus nephritis. This figure shows representative immunohistochemical staining with anti-CD8 of a tonsil which served as positive control (A,B) . Immunhistochemical staining of a lupus nephritis renal biopsy shows an overview (C) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD8 as demonstrated in (D) . Next, representative immunohistochemical staining with anti-CD107a of a tonsil which served as positive control (E,F) . Immunohistochemical staining lupus nephritis renal biopsy shows an overview (G) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD107a as demonstrated in (H) .

Figure Legend Snippet: CD8 + and CD107a + T-cell infiltrates in lupus nephritis. This figure shows representative immunohistochemical staining with anti-CD8 of a tonsil which served as positive control (A,B) . Immunhistochemical staining of a lupus nephritis renal biopsy shows an overview (C) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD8 as demonstrated in (D) . Next, representative immunohistochemical staining with anti-CD107a of a tonsil which served as positive control (E,F) . Immunohistochemical staining lupus nephritis renal biopsy shows an overview (G) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD107a as demonstrated in (H) .

Techniques Used: Immunohistochemical staining, Staining, Positive Control

CD8 + CD107a + immunofluorescence staining. A staining for CD8 Cy3 (red), CD107a FITC (green) and colocalization of CD8/CD107a/DAPI was performed in a tonsil as positive control (A–C) and a representative renal biopsy of an SLE patient with lupus nephritis (WHO class IV) (D–F) . A magnification of a double-positive CD8 + CD107a + kidney infiltrating cell is shown in (G–J) . All scales represent 100 μm.

Figure Legend Snippet: CD8 + CD107a + immunofluorescence staining. A staining for CD8 Cy3 (red), CD107a FITC (green) and colocalization of CD8/CD107a/DAPI was performed in a tonsil as positive control (A–C) and a representative renal biopsy of an SLE patient with lupus nephritis (WHO class IV) (D–F) . A magnification of a double-positive CD8 + CD107a + kidney infiltrating cell is shown in (G–J) . All scales represent 100 μm.

Techniques Used: Immunofluorescence, Staining, Positive Control

Renal CD8 + and CD107a + T-cells. Correlation between the CD8 + T-cell count (cells/mm 2 ) in renal biopsies of nine lupus nephritis patients and renal histopathology parameters activity index (AI), chronicity index (CI) and proteinuria (g/d). The same correlation was performed for CD107a + T-cell count (cells/mm 2 ) in renal biopsies. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Figure Legend Snippet: Renal CD8 + and CD107a + T-cells. Correlation between the CD8 + T-cell count (cells/mm 2 ) in renal biopsies of nine lupus nephritis patients and renal histopathology parameters activity index (AI), chronicity index (CI) and proteinuria (g/d). The same correlation was performed for CD107a + T-cell count (cells/mm 2 ) in renal biopsies. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Techniques Used: Cell Counting, Histopathology, Activity Assay

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Journal: Frontiers in Medicine

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

doi: 10.3389/fmed.2021.556776

Figure Lengend Snippet: Peripheral circulating CD107a + CD8 + T-cells. (A) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), SLE-patients (SLE), (B) patients with lupus nephritis (with LN) and without lupus nephritis (without LN) are shown. (C) The percentages of CD107a + CD8 + T-cells in healthy controls (HC), active SLE-patients (SLE) and inactive patients are shown. Frequencies of these T-cells are shown. Horizontal lines represent the mean. P -values were calculated using the non-parametric Mann-Whitney U-test. (D) Correlation between percentages of CD107a + CD8 + T-cells and disease activity ( n = 30) as assessed by the systemic lupus erythematosus disease activity index (SLEDAI). Spearman analysis was performed to calculate the correlation. A p -value <0.05 was considered significant. (E) A representative dot plot of the flow-cytometry staining is shown for a healthy control (HC), a patient with lupus nephritis (LN) and without LN. The corresponding isotype control is illustrated.

Article Snippet: Incubation with a monoclonal mouse anti-human CD8 (clone C8/144, DAKO, Carpinteria, USA) or polyclonal rabbit anti-human CD107a (polyclonal, Bio-Rad, Munich, Germany) was performed for 60 min at room temperature.

Techniques: MANN-WHITNEY, Activity Assay, Flow Cytometry, Staining, Control

Journal: Frontiers in Medicine

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

doi: 10.3389/fmed.2021.556776

Figure Lengend Snippet: (A) The proportion of CD107a + CD8 + T-cells we were analyzed according to the immunosuppressive treatment. Patients were subgrouped in (i) no treatment or prednisone alone (ii) prednisone and mycophenolate mofetil, azathioprine or cyclosporine (iii) prednisone and hydroxychloroquine (iv) prednisone and hydroxychloroquine combined with mycophenolate mofetil, azathioprine or cyclosporine. Patients were compared to healthy controls (HC). P -values were calculated using the non-parametric Mann-Whitney U-test. (B) Correlation between percentages of CD107a + CD8 + T-cells for all samples taken ( n = 30) daily dose of hydroxychloroquine is shown. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Techniques: MANN-WHITNEY

Journal: Frontiers in Medicine

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

doi: 10.3389/fmed.2021.556776

Figure Lengend Snippet: CD8 + and CD107a + T-cell infiltrates in lupus nephritis. This figure shows representative immunohistochemical staining with anti-CD8 of a tonsil which served as positive control (A,B) . Immunhistochemical staining of a lupus nephritis renal biopsy shows an overview (C) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD8 as demonstrated in (D) . Next, representative immunohistochemical staining with anti-CD107a of a tonsil which served as positive control (E,F) . Immunohistochemical staining lupus nephritis renal biopsy shows an overview (G) with one glomerulum and interstitial lymphocytes. Several of these lymphocytes express CD107a as demonstrated in (H) .

Techniques: Immunohistochemical staining, Staining, Positive Control

Journal: Frontiers in Medicine

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

doi: 10.3389/fmed.2021.556776

Figure Lengend Snippet: CD8 + CD107a + immunofluorescence staining. A staining for CD8 Cy3 (red), CD107a FITC (green) and colocalization of CD8/CD107a/DAPI was performed in a tonsil as positive control (A–C) and a representative renal biopsy of an SLE patient with lupus nephritis (WHO class IV) (D–F) . A magnification of a double-positive CD8 + CD107a + kidney infiltrating cell is shown in (G–J) . All scales represent 100 μm.

Techniques: Immunofluorescence, Staining, Positive Control

Journal: Frontiers in Medicine

Article Title: CD107a + (LAMP-1) Cytotoxic CD8 + T-Cells in Lupus Nephritis Patients

doi: 10.3389/fmed.2021.556776

Figure Lengend Snippet: Renal CD8 + and CD107a + T-cells. Correlation between the CD8 + T-cell count (cells/mm 2 ) in renal biopsies of nine lupus nephritis patients and renal histopathology parameters activity index (AI), chronicity index (CI) and proteinuria (g/d). The same correlation was performed for CD107a + T-cell count (cells/mm 2 ) in renal biopsies. Spearman analysis was performed to calculate the correlation. A p -value < 0.05 was considered significant.

Techniques: Cell Counting, Histopathology, Activity Assay

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